Pregvance SR 300 Tablet is primarily utilised in hormone replacement therapy (HRT) to manage menopausal symptoms in women. It is classified under steroid hormones, specifically progesterone, which plays a pivotal role in the female reproductive system.
Pregvance SR 300 Tablet is used for managing the following conditions:
• Alleviating menopausal symptoms in women with an intact uterus.
• Restoring menstrual periods in premenopausal women experiencing secondary amenorrhoea.
• Supporting the luteal phase of the menstrual cycle in women with infertility issues.
• Maintaining early pregnancy in women prone to recurrent miscarriages.
• Swallow the tablet whole with a glass of water, preferably at bedtime.
• Do not split, chew, or crush the tablet.
• Take this medicine consistently and at the same time each day.
• Do not alter your dosage without consulting your doctor.
• Do not discontinue this medicine without your doctor’s guidance.
Pregvance SR 300 Tablet is taken orally.
Pregvance SR 300 Tablet may lead to the following side effects:
• Headache
• Breast tenderness or pain
• Nausea and bloating
• Dizziness and drowsiness
• Irregular vaginal bleeding or spotting
Pregvance SR 300 Tablet contains natural micronised progesterone (300 mg), which acts in the body by:
• Stimulating the endometrium: Progesterone prepares the uterine lining (endometrium) for pregnancy by causing necessary secretory changes for embryo implantation.
• Supporting pregnancy: It maintains the endometrium during pregnancy, aiding foetal development.
• Inhibiting uterine contractility: Progesterone prevents excessive uterine contractions, potentially averting premature labour.
• Counteracting oestrogen: It mitigates the proliferative effects of oestrogen on the endometrium, thus reducing the risk of endometrial hyperplasia and cancer.
• Promoting breast development: Progesterone assists in the development of breasts and milk production.
• Suppressing LH surge: The hormone acts on the brain to suppress a surge in luteinising hormone, having an anti-ovulatory effect.
Pregvance SR 300 Tablet is contraindicated in pregnancy. If you are pregnant or planning to conceive, consult your doctor before beginning this medicine.
This medicine is contraindicated for breastfeeding women. It is imperative to discuss potential risks and benefits with your doctor.
Consumption of alcohol while taking this medicine may enhance the risk of dizziness and drowsiness.
Exercise caution and consult your doctor before taking this medicine if you have mild to moderate liver impairment. It is not recommended for severe liver diseases.
If you have a history of kidney problems, consult your doctor before using Pregvance SR 300 Tablet.
This medicine may impair cognitive function, causing drowsiness or dizziness. Caution is advised when driving or operating machinery.
Do not use if you have an allergy to progesterone or its ingredients.
Caution is advised while giving this medicine to individuals under 18 years of age. Consult a doctor beforehand.
Older patients should take this medicine under medical supervision, as they may be more susceptible to its side effects, especially if they are over 70 years or have liver and kidney issues.
Drug-Drug Interactions
• Hepatic Enzyme Inducers: These medicines increase liver processing speed, potentially lowering progesterone levels.
• CYP3A4 Inhibitors: They may slow down progesterone breakdown, leading to higher levels.
• Immunosuppressants: Progesterone can increase cyclosporine levels, a medicine preventing organ rejection.
• Antidiabetic Agents: Progesterone may interfere with blood sugar control, affecting medicines like metformin and insulin.
Drug-Disease Interactions
• Breast or Genital Tract Cancers: Progesterone may stimulate growth in hormone-sensitive cancers.
• Thromboembolic Disorders: Hormonal therapies like progesterone may increase the risk of blood clots.
Daily Dosage
• Pregvance SR 300 Tablet should be taken as advised by your doctor. Dosage may be adjusted based on your response and condition severity.
Missed Dose
• If you miss a dose, take it as soon as you remember. If it is near the time for your next dose, skip the missed dose. Never double the dose.
Overdose
• Overdose symptoms may include drowsiness, dizziness, or upset stomach. Consult your doctor if these occur.
• Store in a dry, cool place, away from light and moisture.
• Keep at temperatures not exceeding 30°C.
• Ensure it is out of sight and reach of children.
• Use before the expiration date.
• Include calcium and vitamin D-rich foods to strengthen bone health and prevent osteoporosis.
• Maintain a balanced diet and healthy weight to optimise hormone balance and fertility.
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