Glynux MP 2 Tablet is primarily indicated for the management of type 2 diabetes mellitus in adults. It is a combination medication encompassing the pharmacological classes of sulphonylureas, biguanides, and thiazolidinediones.
Glynux MP 2 Tablet is prescribed for:
• Controlling blood sugar levels in adults with type 2 diabetes
• Complementing dietary adjustments and exercise to enhance glycaemic control
• Assisting individuals inadequately managed by dual combination therapy
• Take the tablet whole with a glass of water.
• Do not crush, cut, or chew the tablet.
• Maintain consistency in timing by taking the medicine at the same time each day.
• Consult your doctor before adjusting the dosage or discontinuing the medicine.
Glynux MP 2 Tablet is taken orally.
Common side effects associated with this tablet include:
• Abdominal pain
• Diarrhoea
• Nausea and vomiting
• Loss of appetite
• Headache and dizziness
Glynux MP 2 Tablet combines three active pharmacological agents:
• Glimepiride (2 mg): This sulphonylurea enhances insulin secretion from the pancreatic beta cells, thus facilitating the regulation of blood glucose levels.
• Metformin (500 mg): A biguanide that decreases hepatic glucose production, reduces intestinal glucose absorption, and augments peripheral insulin sensitivity, thereby lowering blood sugar levels.
• Pioglitazone (15 mg): This thiazolidinedione increases insulin sensitivity in muscle and adipose tissue, improving the effectiveness of insulin utilisation to decrease blood glucose concentrations.
The use of this tablet in pregnancy should be carefully considered, weighing potential benefits against risks to the foetus.
Metformin can be excreted into human milk; therefore, breastfeeding is not recommended while taking this medicine.
Concurrent alcohol consumption may interfere with the medicine's efficacy and elevate the risk of lactic acidosis. Limiting alcohol intake is advisable
Caution is advised.
Caution is advised.
This medicine may induce dizziness or visual disturbances. If such effects occur, refrain from driving or operating machinery.
Individuals with known allergy to glimepiride, metformin, pioglitazone, or any other component should not use the medicine.
The safety and efficacy of this tablet have not been established in children; therefore, its use is not recommended unless specifically advised by a doctor.
Elderly patients may exhibit increased susceptibility to side effects, such as hypoglycaemia and heart failure, necessitating dose adjustments and monitoring. Seek medical advice accordingly.
Drug-Drug Interactions
• Anti-diabetics: Co-administration with insulin or other hypoglycaemic agents may increase the risk of hypoglycaemia.
• Diuretics: When combined with diuretics, there is an elevated risk of heart failure.
• Cationic Medicines: These medicines may inhibit metformin clearance, increasing its plasma concentration.
• CYP2C8 Inducers: Such agents can diminish the concentration of pioglitazone in the system, reducing efficacy.
Drug-Food Interactions
• High-fat Meals: The absorption of glimepiride can be delayed by the ingestion of fatty foods, impacting glycaemic control.
Drug-Disease Interactions
• Heart Disease: Pioglitazone may exacerbate heart failure, necessitating caution in patients with existing cardiac conditions.
• Lactic Acidosis: The use of metformin may lead to lactic acidosis, particularly in individuals with renal or severe hepatic disease.
• Diabetes: This tablet is not recommended for type 1 diabetes or diabetic ketoacidosis management.
• Bladder Cancer: Pioglitazone has been associated with an increased risk of bladder cancer; consult your doctor if you have a history of this malignancy.
Daily Dosage
• This tablet should be taken as prescribed by your doctor.
Missed Dose
• If a dose is missed, take it as soon as remembered. If the next dose is imminent, skip the missed dose and resume the regular schedule. Avoid double dosing.
Overdose
• Overdose may cause dizziness, weakness, or stomach discomfort. Seek immediate medical assistance if symptoms persist.
• Store at room temperature, ideally below 30°C.
• Protect from direct sunlight and moisture.
• Keep out of reach of children.
• Verify the expiry date prior to use.
• Follow a balanced diet rich in fibre, fruits, vegetables, and lean proteins to stabilise blood glucose levels.
• Engage in regular physical activity, such as at least 30 minutes of moderate-intensity brisk walking or cycling, to enhance insulin sensitivity and manage blood sugar.
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