· Igumat 25 Tablet is taken orally.

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Igumat 25 Tablet contains iguratimod (25 mg), which exerts its effects through several mechanisms:

· Inhibition of NF-κB Activation: Iguratimod inhibits NF-κB, a transcription factor that regulates genes responsible for inflammation, thereby diminishing the synthesis of inflammatory cytokines such as IL-1, IL-6, IL-8, and TNF-α.

· Suppression of Antibody Production: It reduces the secretion of immunoglobulins IgG, IgM, and IgA, which are implicated in inflammatory responses.

· Modulation of T Cell Responses: Iguratimod modulates the immune system by decreasing pro-inflammatory Th1 and Th17 cell activity and enhancing anti-inflammatory regulatory T cell function.

· Promotion of Bone Formation: It facilitates osteoblast differentiation and inhibits osteoclast activity, promoting bone formation and counteracting bone resorption.

· Potential Inhibition of Prostaglandin E2 Production: This medicine may decrease prostaglandin E2 synthesis and cyclooxygenase-2 activity, contributing to its anti-inflammatory and analgesic properties.

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Drug-Drug Interactions

· Blood Thinners: This tablet may enhance the anticoagulant effects, necessitating INR monitoring.

· Immunosuppressants: Iguratimod can elevate cyclosporine levels, requiring dose adjustments.

· CYP450 Inducers: These agents may reduce this tablet efficacy.

· CYP450 Inhibitors: These can increase the levels of this tablet, heightening side effect risks.

Drug-Food Interactions

· Dairy Products: Consumption may impair the absorption of this tablet, reducing its efficacy.

Drug-Disease Interactions

· Low White Blood Cell or Platelet Counts: Increased caution is advised due to potential risks.

· Active Infection or Tuberculosis History: The use requires careful evaluation.

· Poorly Controlled Diabetes: Monitoring is essential as this tablet may affect glucose regulation.

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Daily Dosage

· Igumat 25 Tablet should be taken as directed by your doctor, with dosage tailored to your condition.

Missed Dose

· If a dose is missed, take it as soon as possible. If it is nearing the next scheduled dose, skip the missed dose and continue as normal. Do not double the dose.

Overdose

· Symptoms of excessive this tablet include severe nausea, vomiting, and abdominal pain. Seek medical attention promptly.

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· Store this tablet in its original container to protect from light and moisture.

· Keep out of reach of children.

· Verify the expiry date before use and dispose of expired medication appropriately.

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· Engage in low-impact exercises, such as swimming or cycling, to maintain joint health.

· Adopt an anti-inflammatory diet rich in fruits, vegetables, whole grains, lean proteins, and omega-3 fatty acids to mitigate rheumatoid arthritis symptoms.

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